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This is done by a complicated, advanced pharmaceutical method

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Stover, P

Front Pharmacol 10:316 Abadi ATB, Perez-Perez G (2016) Role of dupA in virulence of Helicobacter pylori

Total inactivation of the IGF-I gene in mice produce a perinatal mortality of 80% with the surviving animal showing significant growth retardation compared to controls (75)